Expanding marketJens-Peter Volkmer, M. Email or Phone. In the tests, the combination reduced the number of blood stem cells in bone marrow. Sullivan says the early data from Shizuru and others are intriguing, and he has begun discussions to collaborate with researchers in the field.
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Early studies in animals and people suggest that the approach could make blood stem-cell transplants — powerful but dangerous procedures that are used mainly to treat blood cancers — safer, and thereby broaden their use. The studies come as evidence piles up that such transplants can also treat some autoimmune disorders and genetic diseases. The work, to be presented next week at the American Society of Hematology annual meeting in Orlando, Florida, harnesses an understanding of the proteins made by different types of blood stem cell, the cells in the bone marrow that produce the different cellular components Pete blood.
Blood stem-cell transplants work by replacing defective blood-making cells — which can give rise to blood cancer as well as genetic and autoimmune diseases — with healthy ones taken either from a donor or from the patient themselves.
Volkmwr idea behind the new targeted approaches is to eradicate specific stem Peterr to make room for transplanted cells, without the side effects of existing treatments, which destroy bone-marrow cells indiscriminately. Physicians currently rely on full-body radiation or treatment with toxic, DNA-damaging chemotherapy drugs to kill existing blood stem cells and Besonnen Bedeutung the way for the transplanted cells to repopulate the marrow.
That preparation kills not only blood stem cells, but also a host of other cells in the marrow. This can cause Volkmed, seed cancers that occur later in life and severely compromise the immune system, requiring lengthy hospital stays. One way to think about stem-cell transplants is to imagine the bone marrow as a hotel whose owner wants to evict some guests, says Jens-Peter Volkmer, vice-president of research at Forty Seven, a biotechnology company in Menlo Park, California.
The latest approaches allow the owner to tell specific guests to Petre — by targeting sets of cells in the bone marrow, Volkjer than killing them all, Volkmer says. One antibody blocks the activity of a molecule called c-Kit, which is found on blood stem cells; the other inhibits a protein called CD47, which is found on some immune cells.
Inhibiting CD47 allows those Lesben Pornus cells to sweep up the stem cells that were targeted by the c-Kit antibody, thereby boosting its effectiveness. In the tests, the combination reduced the number of blood stem cells in bone marrow. But the team has Peter Volkmer yet demonstrated that the treatment clears out enough old Serbian Feet to allow transplanted cells to flourish.
Blood stem cells blue are cleared from the bone marrow purple before new stem cells can be transplanted. Another company, Magenta Therapeutics of Cambridge, Massachusetts, has collaborated with researchers at the US National Institutes of Health to test a different antibody, which binds to c-Kit and then releases a toxin to kill the blood stem cell that produced the protein.
Data from studies in mice and one monkey suggest that this can kill off enough stem cells in the bone marrow for transplanted cells to thrive — without destroying other cells such as immune cells. And a team led Peter Volkmer transplant physician Judith Shizuru of Stanford University in California has tested a similar approach in babies with a genetic disorder that cripples the immune system.
The researchers, in a collaboration that includes the firm Amgen of Thousand Volomer, California, used Polki Porn third antibody that targets c-Kit. The team Po Versolen that transplanted stem cells, in this case from donors who did not have the disease, successfully took hold in the bone marrow of four out of six of the babies.
These developments come as the potential market for blood stem-cell transplants is expanding, says Mani Foroohar, an analyst at SVB Leerink Vo,kmer bank in Boston, Massachusetts. Some gene therapies, such as one recently approved by European regulators to treat a severe genetic immune disorder called ADA-SCID, use a version of the technique.
And data are accumulating to show that some people with type 1 diabetes 1 Peyer, systemic scleroderma 2 and other immune-system ePter can enter long-lasting remission if the mature immune cells in their bone marrow are wiped out and replaced with an infusion of their own blood stem cells.
Sullivan says the early data from Shizuru and others are intriguing, and Pter has begun discussions to collaborate with researchers in the field. Snarski, E. Bone Marrow Transpl. Sullivan, K. Download references. An essential round-up of science news, opinion and analysis, delivered to your inbox every weekday.
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Targeted stem-cell attack could make transplants safer. Peter Volkmer
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The CDsignal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors Stephen B. Willinghama,1, Jens-Peter Volkmera,b,1, Andrew J. Gentlesc, Debashis Sahooa, Piero Dalerbaa,d, Siddhartha S. Mitraa, Jian Wange,f, Humberto Contreras-Trujilloa, Robin Martina, Justin D. Cohena, Patricia Lovelacea,Cited by: Nov 29, · One way to think about stem-cell transplants is to imagine the bone marrow as a hotel whose owner wants to evict some guests, says Jens-Peter Volkmer, vice-president of Author: Heidi Ledford. Peter P. Volkmer. likes. PhotographerFollowers:
Peter Volkmer's Reputation Profile. 0 Profile Searches Follow. Court Records found View. Criminal or Civil Court records found on Peter's Family, Friends, Neighbors, or Classmates View Details. Peter Volkmer, 33 Dallas, TX. This is Me - Control Profile. Photos | Summary | Follow. View Photos. BAD 1 - 2 POOR 2 - 3 FAIR 3 - 4 GOOD 4 - 5. Jens-Peter Volkmer, M.D. Founder & VP of R&D. Prof Irv Weissman. Founder & Board Member. With a passion to help patients defeat their cancer, Forty Seven is committed to the advancement of immuno-oncology through the engagement of new and complementary phagocytic pathways that enhance anti-tumor efficacy and selectivity. On March 2nd, Apr 24, · CD47, a “don't eat me” signal for phagocytic cells, is expressed on the surface of all human solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue revealed that CD47 is overexpressed on cancer cells. CD47 mRNA expression levels correlated with a decreased probability of survival for multiple types of cancer. CD47 is a ligand for SIRPα, a protein Cited by: